Buckler Biomedical LLC

We are presently working together with clients in the pursuit of quantitative imaging biomarkers, mechanistic imaging analytics, structural informatics, and computational systems biology.  We apply engineering principles and systems analysis to the underlying detection and modeling problems to characterize biological processes of interest, as well as designing monitoring and control applications exploiting encoded biomedical knowledge.

  Examples include:

• Assessing the suitability of scanner design generations for mechanistic imaging given the time course of the process being quantified as compared to limitations of instrumentation designs vs. characteristics of tracers. 
• Pursuit of system designs for clinical decision support and closed loop control systems using model-based approaches for applications across the cycle of care.  
• Acquisition of training data sets from in-vitro, in-vivo, and ex-vivo assays.
• Development of simulation and modeling techniques well-matched for the interpretation and quantitative characterization of pathogenic processes.
• Pursuit of increasingly sensitive and specific measurement methodology for the collection of both training and validation data sets.
• Computational runs of models to predict biological behavior.
• Validation of predicted results based on quantitative in-vivo measurements.
• Theoretical and practical aspects of computational complexity associated with the methods.

Examples include: